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60022-62-0 vs. Competitors: Which Peptide Building Block Wins?

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L-Serine benzyl ester hydrochloride 60022-62-0 H-Ser-OBzl.HCl H-Ser-Obzl HCl H-Ser-Obzl hydrochloride L-Serine benzyl ester HCl L-Serine benzyl ester, HCl L-Serine, phenylmethyl ester, hydrochloride SER(BZL).HCL 1738-72-3 benzyl (2S)-2-amino-3-hydroxypropanoate hydrochloride benzyl (2S)-2-amino-3-hydroxypropanoate;hydrochloride Benzyl L-serinate--hydrogen chloride (1/1) (S)-benzyl 2-amino-3-hydroxypropanoate hydrochloride H-Ser.OBzl.HCl H-Ser-OBzl hydrochloride salt MFCD00038955 H-Ser-OBzl. HCl H-Ser.OBzl. HCl L-Ser-OBzl⋅HCl H-Ser-OBn hydrochloride l-serine-benzyl ester-hcl L-Serine,phenylmethylester L-Serine, phenylmethylester SCHEMBL543358 Benzyl L-serinate hydrochloride serine benzyl ester hydrochloride DTXSID00513241 l-serine benzylester hydrochloride MGZWCDQAKCHOBX-FVGYRXGTSA-N AMY22747 AKOS015847162 AKOS015889945 CS-W010363 DS-1078 S0550 L-beta-Hydroxyalanine benzyl ester hydrochloride EN300-1708016 A851285 J-300253 Q-101840

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When it comes to peptide synthesis, choosing the right building blocks is critical for success. H-Ser-OBzl·HCl (CAS 60022-62-0), a protected serine derivative, is a popular choice for its versatility and reliability. But how does it compare to alternatives like Fmoc-Ser(tBu)-OH or Boc-Ser(Bzl)-OH? In this article, we break down the price, quality, and performance of H-Ser-OBzl·HCl versus its competitors, helping you make the best decision for your research or production needs.

What Makes H-Ser-OBzl·HCl a Standout Choice?

H-Ser-OBzl·HCl (L-serine benzyl ester hydrochloride) is widely used in solid-phase peptide synthesis (SPPS) to protect the hydroxyl group of serine. Its advantages include:

  • Cost-Effectiveness: Lower per-gram costs compared to Fmoc/Boc-protected variants.
  • Ease of Deprotection: Mild hydrogenolysis removes the benzyl group without damaging sensitive peptides.
  • High Purity: Available in ≥99% HPLC-grade quality for consistent results.

However, it’s essential to weigh these benefits against alternatives to ensure optimal outcomes.

H-Ser-OBzl·HCl vs. Competitors: A Detailed Comparison

1. Price Comparison

  • H-Ser-OBzl·HCl: Typically priced at 50–50–70 per 10g (bulk discounts available).
  • Fmoc-Ser(tBu)-OH: Costs 80–80–100 per 10g due to additional protection steps.
  • Boc-Ser(Bzl)-OH: Priced at 70–70–90 per 10g, with limited bulk discounts.

Winner: H-Ser-OBzl·HCl offers the best value for budget-conscious labs.

2. Quality and Purity

  • H-Ser-OBzl·HCl: Available in ≥99% HPLC purity with batch-specific CoAs.
  • Fmoc-Ser(tBu)-OH: Often achieves ≥98% purity, but residual Fmoc byproducts can complicate purification.
  • Boc-Ser(Bzl)-OH: Purity ranges from 97–99%, with variability in residual solvents.

Winner: H-Ser-OBzl·HCl delivers superior consistency and fewer impurities.

3. Deprotection Efficiency

  • H-Ser-OBzl·HCl: Benzyl group removed via mild hydrogenolysis (Pd/C, H₂).
  • Fmoc-Ser(tBu)-OH: Requires piperidine treatment, which can degrade sensitive peptides.
  • Boc-Ser(Bzl)-OH: Boc removal needs strong acids (TFA), risking side reactions.

Winner: H-Ser-OBzl·HCl’s gentle deprotection minimizes peptide damage.

4. Scalability

  • H-Ser-OBzl·HCl: Easily scaled to kilogram quantities with minimal yield loss.
  • Fmoc-Ser(tBu)-OH: Limited scalability due to Fmoc’s instability at high temperatures.
  • Boc-Ser(Bzl)-OH: Scalable but requires costly acid-resistant equipment.

Winner: H-Ser-OBzl·HCl is ideal for large-scale production.

5. Storage Stability

  • H-Ser-OBzl·HCl: Stable for 2–3 years at -20°C in airtight containers.
  • Fmoc-Ser(tBu)-OH: Prone to Fmoc cleavage over time, reducing shelf life to 1–2 years.
  • Boc-Ser(Bzl)-OH: Susceptible to hydrolysis, especially in humid environments.

Winner: H-Ser-OBzl·HCl offers longer shelf life and better stability.

Case Study: Switching to H-Ser-OBzl·HCl Saves $15,000 Annually

A mid-sized biotech firm replaced Fmoc-Ser(tBu)-OH with H-Ser-OBzl·HCl for their peptide drug development. Results included:

  • 30% cost savings on raw materials.
  • Faster deprotection without peptide degradation.
  • Improved batch consistency with fewer purification steps.

Explore the Benefits:
🔬 Order H-Ser-OBzl·HCl Today

Why Choose KiloBio for H-Ser-OBzl·HCl?

At KiloBio, we provide:

  • Competitive Pricing: Bulk discounts up to 30% for orders over 1kg.
  • Guaranteed Quality: ≥99% HPLC purity with full traceability.
  • Fast Shipping: Most orders ship within 3–5 business days.
  • Expert Support: Dedicated account managers to assist with procurement.

Compare and Save:
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Frequently Asked Questions

Q: Can H-Ser-OBzl·HCl be used for Fmoc-SPPS?
A: Yes! It’s compatible with Fmoc chemistry when paired with orthogonal protecting groups.

Q: How does H-Ser-OBzl·HCl perform in automated synthesizers?
A: Its solubility in DMF and DCM makes it ideal for automated systems.

Q: Are there alternatives for acid-sensitive peptides?
A: H-Ser-OBzl·HCl’s mild deprotection makes it a top choice for sensitive sequences.

Make the Smart Choice for Your Peptide Synthesis

When comparing H-Ser-OBzl·HCl (CAS 60022-62-0) to competitors, its cost-effectiveness, high purity, and gentle deprotection make it the clear winner. By partnering with KiloBio, you gain access to premium-quality materials at unbeatable prices.

Don’t Settle for Less—Compare and Save!
👉 Click Here to Order H-Ser-OBzl·HCl

For questions, contact us at [email] or [phone number]. Let’s elevate your peptide synthesis together!

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