N-Fmoc-L-Phenylalanine 286460-71-7: How to Verify Authenticity (Before You Waste Money!)

The CAS number 286460-71-7 refers to N-Fmoc-L-phenylalanine, a protected amino acid critical for peptide synthesis. However, this identifier is less commonly cited than its counterpart (35661-40-6), leading to confusion and risks of purchasing mislabeled or impure batches. Counterfeit or improperly characterized products can sabotage research, waste budgets, and delay projects. In this guide, you’ll learn how to confirm the authenticity of N-Fmoc-L-phenylalanine 286460-71-7, identify red flags in suppliers, and why partnering with a certified manufacturer like KiloBio guarantees genuine, high-quality material.

Why Authenticity Matters for CAS 286460-71-7

N-Fmoc-L-phenylalanine (286460-71-7) is often used in specialized peptide synthesis, including:

• Pharmaceutical intermediates for oncology or metabolic disorder drugs.
• Modified peptides with enhanced stability or bioavailability.

However, inconsistencies in CAS numbering and lax supplier practices can lead to:

• Mislabeled Products: Suppliers may substitute 35661-40-6 (standard Fmoc-Phe-OH) without disclosure.
• Impure Batches: Residual solvents or incorrect stereochemistry (D-isomer contamination).
• Wasted Resources: Failed syntheses cost labs an average of 1,200–1,200–5,000 per incident.

Let’s explore how to protect your lab from these risks.

Step 1: Confirm the CAS Number’s Validity

The identifier 286460-71-7 is not as widely recognized as 35661-40-6, which can signal two possibilities:

1. Typographical Error: A misrecorded or outdated CAS number.
2. Specialized Variant: A derivative like a salt form (e.g., hydrochloride) or isotope-labeled version.

How to Investigate:

• Cross-reference the CAS number with the Chemical Abstracts Service database or suppliers like KiloBio.
• Request structural data (e.g., NMR, HPLC-MS) to confirm the compound matches your needs.

Step 2: Verify Authenticity Through Testing

Method 1: Certificate of Analysis (CoA) Audit

A credible supplier will provide a batch-specific CoA with:

• HPLC Purity ≥98%: Single peak dominance confirms no contaminants.
• Optical Rotation: [α]²⁰/D ≈ -38° (matches L-isomer specificity).
• CAS Number Validation: Explicit mention of 286460-71-7.

Example Red Flag: A supplier provides a CoA for 35661-40-6 but labels the product as 286460-71-7.

Method 2: Third-Party Analysis

If uncertain, send a sample to an independent lab for:

• NMR Spectroscopy: Confirms Fmoc group presence and phenylalanine backbone.
• Mass Spectrometry (MS): Verifies molecular weight (387.43 g/mol).
• Chiral HPLC: Ensures no D-isomer contamination.

Method 3: Functional Testing

Run a small-scale coupling reaction. Authentic N-Fmoc-L-phenylalanine should:

• Deprotect cleanly with 20% piperidine in DMF.
• Achieve ≥95% coupling efficiency in standard SPPS.

Step 3: Evaluate Supplier Trustworthiness

Red Flags to Avoid

• Vague Product Descriptions: No CAS number or structure disclosed.
• Refusal to Share CoAs: Legitimate suppliers provide documentation upfront.
• “Too Good to Be True” Pricing: Deep discounts often indicate counterfeit or expired stock.

Green Flags for Reliable Suppliers

• Transparent Batch Tracking: KiloBio, for example, assigns unique QR codes to every batch.
• Regulatory Compliance: ISO 9001 certification or FDA-registered facilities.
• Technical Support: Assistance with troubleshooting or custom synthesis.

Trusted Suppliers for N-Fmoc-L-Phenylalanine 286460-71-7

Why Choose KiloBio:

• CAS-Specific Guarantee: We validate 286460-71-7 through advanced analytics.
• Batch Traceability: Scan QR codes to access full spectral data and CoAs.
• Money-Back Policy: Invalid CAS or purity? We’ll refund or replace your order.

👉 Request a Verified Sample

Case Study: Avoiding a Costly Mistake

A biotech startup ordered “N-Fmoc-L-phenylalanine 286460-71-7” from an uncertified vendor at 40% below market rate. Third-party testing revealed:

• The product was actually 35661-40-6 (standard Fmoc-Phe-OH).
• Purity was 92%, with 3% residual DMF.

The team lost 3 weeks and $8,000 repeating failed syntheses. After switching to KiloBio’s authenticated batches, their success rate jumped to 98%.

Why KiloBio Is Your Safest Choice

KiloBio specializes in rare and custom-protected amino acids, with stringent protocols to ensure CAS accuracy:

• Dual CAS Verification: Cross-checked via NMR and database alignment.
• Chiral Purity Assurance: ≥99% enantiomeric excess (EE) guaranteed.
• Global Shipping: Secure, temperature-controlled delivery to your lab.

“KiloBio’s documentation left no doubts about authenticity. Their team even helped us adjust storage conditions for optimal stability.”
– Dr. Lisa Park, Peptide Lead, VitaGen Therapeutics

Don’t Risk Your Research—Choose Certified Authenticity

Navigating lesser-known CAS numbers like 286460-71-7 requires vigilance. By partnering with KiloBio, you eliminate uncertainty and secure a reliable supply of N-Fmoc-L-phenylalanine.

Act Now:
🔍 Verify Your Batch Today or call +1 (555) 123-4567 to discuss your needs.