Fmoc-Ala-OH (CAS 35661-39-3), or 9-Fluorenylmethoxycarbonyl-L-alanine, is a foundational building block in peptide synthesis. Whether you’re a researcher developing therapeutic peptides or a lab manager sourcing reagents, finding a reliable supplier for high-purity Fmoc-Ala-OH is critical. With the rise of online chemical marketplaces, identifying trustworthy vendors can be challenging—especially when quality and consistency directly impact your results.
This guide simplifies your search by highlighting the top 5 suppliers of Fmoc-Ala-OH in 2025, along with key criteria to evaluate before purchasing. We’ll also explain why partnering with specialized manufacturers like Kilobio ensures superior product quality and seamless procurement.
What is Fmoc-Ala-OH (CAS 35661-39-3)?
Fmoc-Ala-OH is a protected derivative of L-alanine, an amino acid essential for constructing peptides and proteins. The Fmoc (9-fluorenylmethoxycarbonyl) group shields the amino terminus during solid-phase peptide synthesis (SPPS), enabling precise, stepwise chain elongation. Key applications include:
- Drug development: Synthesizing peptide-based therapeutics.
- Biomaterials: Engineering hydrogels and bioactive surfaces.
- Academic research: Studying protein interactions and enzyme mechanisms.
With the CAS registry number 35661-39-3, this compound is standardized for purity (typically ≥98%) and stability, making supplier reliability a top priority.
Why Your Choice of Supplier Matters
Substandard Fmoc-Ala-OH can introduce impurities, reduce coupling efficiency, and derail months of research. Here’s what to prioritize when selecting a supplier:
- Certifications: ISO 9001, cGMP, or ISO 13485 compliance.
- Purity Guarantees: Access to certificates of analysis (CoA) via HPLC or NMR.
- Scalability: Flexibility to order small batches or bulk quantities.
- Logistics: Temperature-controlled shipping to preserve reagent integrity.
- Technical Support: Expertise to troubleshoot synthesis challenges.
Top 5 Trusted Suppliers of Fmoc-Ala-OH in 2025
1. Kilobio
Kilobio is a leading manufacturer of peptide synthesis reagents, renowned for its:
- High-Purity Standards: Every batch undergoes rigorous QC testing to ensure ≥98% purity.
- Global Shipping: Reliable, temperature-controlled delivery to labs worldwide.
- Custom Solutions: Tailored packaging (1g to 1kg) and bulk discounts.
- Dedicated Support: Expert guidance for SPPS optimization and reagent selection.
Why Choose Kilobio?
Kilobio specializes in Fmoc-protected amino acids, including Fmoc-Ala-OH, and offers unparalleled transparency with instant access to CoAs. Their team works closely with clients to meet project-specific needs, from academic research to industrial-scale production.
Submit an Inquiry: Contact Kilobio for pricing, bulk quotes, or custom synthesis requests.
2. Sigma-Aldrich (Merck)
A household name in lab chemicals, Sigma-Aldrich provides:
- Verified CAS 35661-39-3 products with extensive documentation.
- Fast shipping options in North America and Europe.
Drawback: Higher costs compared to niche suppliers.
3. Bachem AG
A Swiss-based leader in peptide chemistry, Bachem offers:
- Pharma-grade Fmoc-Ala-OH compliant with GMP/GLP standards.
- Comprehensive regulatory support for clinical-stage projects.
4. ChemPep Inc.
Ideal for academic budgets:
- Affordable pricing for small-scale orders (1g to 100g).
- Fast turnaround times for U.S.-based researchers.
5. Thermo Fisher Scientific
Best for bundled purchases:
- Pair Fmoc-Ala-OH with resins, solvents, or coupling reagents.
- Subscription-based restocking for high-volume labs.
5 Key Questions to Ask Before Purchasing
- “Can you share a recent Certificate of Analysis?”
Verify purity (>98%), residual solvent levels, and solubility data. - “What packaging options do you offer?”
Ensure airtight, light-resistant containers to prevent degradation. - “Do you provide technical documentation for regulatory submissions?”
Critical for pharmaceutical or clinical applications. - “What is your lead time for bulk orders?”
Avoid project delays with clear timelines. - “Do you offer synthesis support?”
Suppliers like Kilobio provide troubleshooting for coupling efficiency or deprotection issues.
The Advantage of Specialized Manufacturers
General chemical suppliers often lack the infrastructure to handle moisture- and temperature-sensitive reagents like Fmoc-Ala-OH. Specialized manufacturers invest in:
- Dedicated Facilities: Minimize cross-contamination with peptide-specific production lines.
- Stability Testing: Guaranteed shelf life under recommended storage conditions (-20°C, desiccated).
- Regulatory Expertise: Pre-formatted documentation for FDA/EMA compliance.
For example, Kilobio’s Fmoc-Ala-OH is produced in state-of-the-art facilities with ISO 9001 certification, ensuring reliability for critical research.
Explore Kilobio’s Peptide Synthesis Portfolio
Beyond Fmoc-Ala-OH, Kilobio offers a suite of high-quality reagents to streamline your peptide synthesis workflow:
- Fmoc-Protected Amino Acids: Gly, Val, Leu, and more.
- Orthogonal Protection Reagents: Fmoc-Lys(Boc)-OH, Fmoc-Ser(tBu)-OH.
- Coupling Agents: HOBt, HBTU, and OxymaPure.
Inquire Now to discuss custom synthesis, bulk pricing, or expedited shipping options.
Final Recommendations
Choosing the right Fmoc-Ala-OH supplier impacts your research’s success, cost-efficiency, and timeline. While global distributors like Sigma-Aldrich offer convenience, specialized manufacturers like Kilobio provide superior quality, customization, and technical expertise tailored to peptide synthesis.
Ready to Order? Visit Kilobio’s Fmoc-Ala-OH Product Page to submit an inquiry or request a quote. Their team responds within 24 hours to ensure your project stays on schedule.
