When optimizing hormonal health or recovering from a steroid cycle, the choice between Clomifene (Clomid) and Enclomifene (Enclomiphene) often comes down to cost versus effectiveness. While Clomifene is cheaper upfront, Enclomifene’s precision and safety profile make it a smarter long-term investment for athletes, researchers, and clinicians.
In this guide, we’ll break down the price per mg, hidden costs, and biological benefits of both compounds—and reveal where to source high-purity Enclomifene citrate for maximum value.
What Are Clomifene and Enclomifene?
Clomifene (Clomid)
Clomifene is a 50/50 mix of two isomers:
- Enclomifene (trans-Clomiphene): Blocks estrogen receptors, stimulating testosterone production.
- Zuclomifene (cis-Clomiphene): Acts as an estrogen agonist, linked to side effects like bloating and mood swings.
Enclomifene (Enclomiphene)
Enclomifene is the purified trans-isomer of Clomiphene. It lacks Zuclomifene’s estrogenic activity, making it safer and more effective for:
- Post-cycle therapy (PCT).
- Treating hypogonadism.
- Preserving lean muscle mass.
Clomifene vs. Enclomifene: Cost Per Mg Comparison
| Compound | Avg. Price per 25 mg | Estrogen Activity | Typical Dosage for PCT | Cost per Cycle (6 Weeks) |
|---|---|---|---|---|
| Clomifene | 1.50–1.50–2.50 | High (Zuclomifene) | 50 mg/day | 126–126–210 |
| Enclomifene | 2.50–2.50–4.00 | None | 25 mg/day | 105–105–168 |
Key Takeaways
- Enclomifene is 30–60% more expensive per mg, but its targeted action allows for half the dosage of Clomifene.
- Over a 6-week PCT cycle, Enclomifene often costs less overall due to lower dosing and fewer side-effect management expenses.
3 Reasons Enclomifene’s Higher Price Delivers Better Value
1. Zero Estrogenic Side Effects
Zuclomifene in Clomifene binds to estrogen receptors in fat cells and the brain, causing:
- Bloating and water retention.
- Mood swings (“Clomid cry”).
- Gynecomastia (in rare cases).
Enclomifene’s pure trans-isomer formulation eliminates these risks, saving you money on:
- Aromatase inhibitors (e.g., Anastrozole).
- Mood stabilizers or diuretics.
2. Faster, More Reliable Testosterone Recovery
A 2012 study found Enclomifene increased testosterone by 68% in hypogonadal men vs. Clomifene’s 42%. Its precision reduces the need for extended PCT cycles or repeat treatments.
3. Long-Term Hormonal Health
Clomifene’s estrogenic activity can suppress natural testosterone over time, potentially leading to costly TRT dependency. Enclomifene supports sustainable hormonal balance.
The Hidden Costs of “Cheap” Clomifene
While Clomifene’s lower price per mg is tempting, consider these often-overlooked expenses:
- Higher Dosages Needed: Clomifene requires 50–100 mg/day vs. Enclomifene’s 12.5–25 mg/day.
- Side Effect Management: Bloating or gynecomastia may require additional medications.
- Failed Cycles: Impure Clomifene batches (common with budget suppliers) can derail recovery, wasting time and money.
Where to Buy Pure Enclomifene Citrate
For researchers and clinicians, Kilobio offers 99% pure Enclomifene citrate (CAS 15690-57-0)—the gold standard for safety and efficacy.
Why Choose Kilobio?
- Third-Party Verified: Every batch includes a Certificate of Analysis (CoA) confirming purity and isomer ratio.
- Bulk Discounts: Save up to 25% on larger orders.
- Global Compliance: Meets USP/NF and ISO standards for pharmaceutical-grade quality.
👉 Inquire about Enclomifene citrate pricing and bulk discounts here.
FAQs: Clomifene vs. Enclomifene
Q: Is Enclomifene legal without a prescription?
A: In the U.S., Enclomifene is legal for research use. Human consumption requires a prescription.
Q: Can I substitute Clomifene for Enclomifene?
A: Not safely. Clomifene’s zuclomifene content increases side effect risks.
Q: Why is Enclomifene more expensive per mg?
A: Isolating the trans-isomer requires advanced manufacturing, but its efficiency offsets costs long-term.
The Bottom Line
While Clomifene’s upfront cost per mg is lower, Enclomifene’s precision, safety, and dosage efficiency make it the clear winner for value. By investing in pharmaceutical-grade Enclomifene from trusted suppliers like Kilobio, you prioritize results, health, and long-term savings.
Don’t let short-term savings compromise your goals.
📩 Contact Kilobio today to request a CoA, bulk pricing, or expert guidance on Enclomifene citrate.
