Comprehensive linker chemistry expertise covering amide, urea, click, and PEG-based scaffolds to enable precise, stable, and tunable PROTAC and degrader design.
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From ligand scouting to linker design and conjugation—reliable chemistry, clear analytics and documentation for degraders.
Custom design and synthesis of protein-of-interest and E3 ligase ligands with verified activity.
Diverse linker libraries enabling rapid structure–activity optimization for effective degrader design.
High-purity isolation and full analytical characterization ensuring identity, potency, and consistency.
Route scouting, analog expansion and SAR‐driven modifications.
Synthesis/sourcing of CRBN/VHL/MDM2/cIAP/others under request.
Alkyl/PEG/aromatic linkers; azide/alkyne/amine/carboxyl handles; cleavable motifs.
Copper‑catalyzed click, amide coupling, carbonate/urethane; prep HPLC purification.
LC‑MS, HPLC/UPLC purity, NMR as needed; residual solvent/water tests on request.
CoA/CoT, spectra/chromatograms, batch records and method summaries.
Comprehensive linker chemistry expertise covering amide, urea, click, and PEG-based scaffolds to enable precise, stable, and tunable PROTAC and degrader design.
Expertise in stable linkage formation for efficient PROTAC and degrader conjugation strategies.
Versatile chemistries enabling selective attachment and optimal linker performance.
Reliable copper-catalyzed and strain-promoted click reactions for biocompatible coupling.
Tailored PEG-based or rigid linkers for precise spatial control and tunable pharmacokinetics.
