Fmoc-Ala-OH (CAS 35661-39-3) is a cornerstone reagent in peptide synthesis, but its moisture sensitivity and instability can lead to degradation if not stored properly. Improper storage not only wastes money but also compromises experimental results. Whether you’re a seasoned researcher or new to peptide chemistry, understanding Fmoc-Ala-OH storage guidelines is essential to maintaining reagent integrity and extending shelf life.
In this guide, we’ll share expert storage hacks, highlight key factors that impact stability, and explain why sourcing high-purity Fmoc-Ala-OH from trusted suppliers like Kilobio ensures long-lasting performance.
What is Fmoc-Ala-OH?
Fmoc-Ala-OH (9-Fluorenylmethoxycarbonyl-L-alanine) is a protected amino acid used in solid-phase peptide synthesis (SPPS). The Fmoc group shields the amine terminus during chain assembly, enabling precise, stepwise elongation of peptides. Applications include:
- Drug development: Synthesizing peptide-based therapeutics.
- Biomaterials: Engineering bioactive surfaces.
- Academic research: Studying protein interactions.
With CAS 35661-39-3, Fmoc-Ala-OH is standardized for purity (≥98%) and stability. However, improper storage can lead to degradation, reducing its effectiveness.
Why Proper Storage Matters
Fmoc-Ala-OH is highly sensitive to:
- Moisture: Hydrolysis can degrade the Fmoc group.
- Light: UV exposure can cause photodegradation.
- Temperature: High temperatures accelerate decomposition.
- Oxygen: Oxidation can alter the chemical structure.
Improper storage can result in:
- Reduced Purity: Degraded reagents hinder peptide elongation.
- Wasted Resources: Degraded Fmoc-Ala-OH must be discarded.
- Increased Costs: Frequent reorders strain budgets.
Expert Storage Guidelines for Fmoc-Ala-OH
1. Temperature Control
- Ideal Temperature: Store at -20°C in a freezer.
- Short-Term Storage: For daily use, keep at 4°C in a desiccator.
2. Moisture Protection
- Desiccator: Store in a desiccator with silica gel or Drierite.
- Airtight Containers: Use argon-flushed, light-resistant vials to minimize exposure.
3. Light Protection
- Amber Vials: Use amber or opaque containers to block UV light.
- Dark Storage: Keep in a dark cabinet or drawer.
4. Labeling and Organization
- Label Clearly: Include the chemical name, CAS number (35661-39-3), and date of receipt.
- First-In, First-Out (FIFO): Use older batches first to prevent expiration.
How to Handle Fmoc-Ala-OH Safely
- Work in a Dry Environment: Use dry solvents and tools to prevent hydrolysis.
- Minimize Exposure: Handle small quantities at a time to reduce degradation risks.
- Reseal Immediately: Tightly seal containers after each use.
Signs of Degraded Fmoc-Ala-OH
- Discoloration: Yellow or brown hues indicate oxidation.
- Clumping: Moisture absorption causes clumping.
- Reduced Solubility: Degraded reagents may not dissolve properly.
If you notice these signs, discard the reagent and order a fresh batch from a trusted supplier like Kilobio.
Why Choose High-Purity Fmoc-Ala-OH from Kilobio?
Kilobio is a trusted supplier of peptide synthesis reagents, offering:
- High-Purity Standards: Every batch undergoes rigorous QC testing (≥98% purity).
- Proper Packaging: Argon-flushed, desiccated vials to prevent degradation.
- Transparency: Instant access to CoAs for compliance.
- Expert Support: Dedicated chemists assist with storage and handling queries.
Sample CoA Metrics:
- Purity: 99.2% (HPLC).
- Residual Solvents: <0.05% TFA.
- Water Content: 0.3%.
Submit an Inquiry: Contact Kilobio for pricing, bulk quotes, or custom synthesis requests.
FAQs: Fmoc-Ala-OH Storage
Q: Can I store Fmoc-Ala-OH at room temperature?
A: No. Store at -20°C in a desiccator to prevent degradation.
Q: How long does Fmoc-Ala-OH last when stored properly?
A: Up to 12 months when stored at -20°C in airtight, desiccated containers.
Q: What should I do if my Fmoc-Ala-OH clumps?
A: Discard it. Clumping indicates moisture absorption and degradation.
The Hidden Costs of Improper Storage
Improper storage can lead to:
- Degraded Reagents: Reduced purity and performance.
- Wasted Resources: Frequent reorders increase costs.
- Failed Experiments: Impurities hinder peptide elongation.
Suppliers like Kilobio ensure high-purity Fmoc-Ala-OH, minimizing these risks.
Final Recommendations
To maximize the shelf life of Fmoc-Ala-OH:
- Store at -20°C in a desiccator.
- Use airtight, light-resistant containers.
- Source high-purity reagents from trusted suppliers like Kilobio.
Ready to Order? Visit Kilobio’s Fmoc-Ala-OH Product Page to submit an inquiry or request a quote. Their team responds within 24 hours to assist with your needs.
