Sintesi di peptidi in fase solida (SPPS)

Peptide Manufacturing

Sintesi di peptidi in fase solida (SPPS)

Reliable Fmoc/tBu SPPS for short and long peptides—optimized for yield, purity and scalability with robust analytics and documentation.

Fmoc/tBu SPPS

Reliable solid-phase peptide synthesis ensuring high purity, sequence fidelity, and scalability.

Prep HPLC & LC-MS

Advanced purification and analytical verification for precise peptide identity and quality.

Lyophilized Aliquots

Stable, ready-to-use lyophilized peptide portions for convenient storage and handling.

CAPACITÀ

Capacità principali

We design sequence‑appropriate strategies (Fmoc/tBu) with orthogonal protections, optimized coupling/deprotection, and sequence‑specific additives to deliver high purity at scale.

Solid‑Phase Peptide Synthesis (SPPS)-CDMO for Pharm & Bio | Kilo Biotechnology
Fmoc/tBu chemistry

Fmoc/tBu chemistry for linear and long peptides (up to ~60 aa, sequence‑dependent)

On‑resin cyclization

On‑resin cyclization/disulfide formation and selective deprotection

Motifs mitigation

Difficult motifs mitigation: pseudoproline, backbone protection, chaotropic agents

LPPS/hybrid

LPPS/hybrid steps for challenging segments

Procedura

Equipment & resins

Automated Synthesizers & Heated Reactors

High-efficiency automated systems enabling precise, reproducible peptide synthesis at various scales.

Low-Loading Resins for Long Peptides

PEG-based resins optimized for high-yield synthesis of long or complex peptide sequences.

Prep HPLC, LC-MS & Lyophilization

Integrated purification, analytical confirmation, and lyophilization for final peptide formulation.

Cosa forniamo

Cosa forniamo

Linear & cyclic peptides

SPPS as the primary platform with LPPS/hybrid for long or difficult sequences.

Modifications & conjugates

Amidation/acetylation, disulfides, stapling, PEGylation, lipidation, dyes/biotin.

Purity & formats

Crude → >98% options; lyophilized powder or solution; salt/counter‑ion control.

Peptide libraries

Custom plates for screening; delivered in 96‑well formats with traceability.

SIL peptides

Stable‑isotope labeled peptides for proteomics and quantification workflows.

QC & docs

HPLC/UPLC and MS identity; CoA/CoT; additional reports available on request.

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