N-Fmoc-L-phenylalanine (CAS 286460-71-7) is a critical reagent for peptide synthesis, but its ambiguous CAS number can make sourcing a challenge. Many suppliers mislabel or substitute this compound, leading to wasted time, budget overruns, and failed experiments. This guide provides a roadmap to sourcing authentic N-Fmoc-L-phenylalanine quickly and affordably, while avoiding common pitfalls. Plus, learn why KiloBio is a trusted partner for niche peptide synthesis reagents.
Why Sourcing N-Fmoc-L-Phenylalanine (286460-71-7) Is Tricky
The CAS number 286460-71-7 is less commonly cited than its counterpart (35661-40-6), leading to confusion and risks such as:
- Mislabeled Products: Suppliers may substitute standard Fmoc-Phe-OH without disclosure.
- Inconsistent Quality: Impure or degraded batches disrupt synthesis workflows.
- Limited Availability: Few suppliers stock this specific variant, leading to long lead times.
By following these strategies, you can source authentic N-Fmoc-L-phenylalanine without overspending.
Step 1: Verify the CAS Number’s Validity
Before placing an order, confirm that 286460-71-7 matches your needs:
- Cross-Reference Databases: Use the Chemical Abstracts Service (CAS) or PubChem to validate the identifier.
- Request Structural Data: Ask suppliers for NMR or HPLC-MS spectra to confirm the compound’s identity.
Pro Tip: If the CAS number is incorrect or outdated, clarify the exact compound you need (e.g., a salt form or isotope-labeled variant).
Step 2: Compare Trusted Suppliers
Not all suppliers are created equal. Here’s how to evaluate potential vendors:
1. Transparency
- Do they provide batch-specific CoAs?
- Can they confirm the CAS number matches their product?
2. Testing Protocols
- Look for HPLC-MS validation to ensure ≥98% purity.
- Verify optical rotation ([α]²⁰/D ≈ -38°) to confirm L-configuration.
3. Pricing and Lead Times
- Compare quotes from multiple suppliers to avoid overpaying.
- Confirm shipping times and MOQs (minimum order quantities).
Top Suppliers for N-Fmoc-L-Phenylalanine (286460-71-7)
| Supplier | Purity | Price (10g) | Lead Time | Best For |
|---|---|---|---|---|
| KiloBio | ≥99% | $280 | 1–2 weeks | Best value + quality |
| Sigma-Aldrich | ≥98% | $350 | 2–4 weeks | Established partnerships |
| Bachem | ≥99% | $320 | 3–5 weeks | GMP-grade materials |
| TCI Chemicals | ≥97% | $300 | 3–6 weeks | General research |
| Alfa Chemistry | ≥98% | $290 | 4–8 weeks | Custom synthesis |
Why KiloBio Stands Out:
- CAS-Specific Guarantee: We validate 286460-71-7 through advanced analytics.
- Batch Traceability: QR codes link to spectral data and CoAs.
- Flexible MOQs: Order from 10g to 25kg with no hidden fees.
Step 3: Verify Authenticity Before Use
Even with a trusted supplier, it’s wise to confirm authenticity:
1. Third-Party Testing
- Send a sample to an independent lab for NMR or HPLC-MS analysis.
- Confirm molecular weight (387.43 g/mol) and optical rotation.
2. Functional Testing
- Perform a small-scale coupling reaction.
- Monitor coupling efficiency and deprotection clarity.
3. Visual Inspection
- Check for discoloration (yellow or brown tints indicate oxidation).
- Avoid clumped or powdery textures, which suggest moisture exposure.
Cost-Saving Tips for Sourcing N-Fmoc-L-Phenylalanine
1. Buy in Bulk
- Suppliers like KiloBio offer discounts for orders >5kg.
- Split costs with other labs to meet MOQs.
2. Negotiate Long-Term Contracts
- Lock in rates by committing to quarterly or annual purchases.
- Request free shipping or waived customs fees.
3. Monitor Promotions
- End-of-quarter or holiday sales can save 15–20%.
- Subscribe to supplier newsletters for exclusive deals.
Why KiloBio Is Your Best Source for N-Fmoc-L-Phenylalanine
KiloBio specializes in niche peptide synthesis reagents, offering:
1. Guaranteed Authenticity
- Every batch is validated for CAS 286460-71-7 through HPLC-MS and NMR.
- Free sample CoAs available upon request.
2. Competitive Pricing
- Direct manufacturing reduces costs by 20–30% compared to distributors.
- Bulk discounts for orders >5kg.
3. Global Logistics
- Temperature-controlled shipping ensures product integrity worldwide.
- Real-time order tracking via a secure portal.
“KiloBio’s N-Fmoc-L-phenylalanine is the only supplier we trust for our peptide library projects. Their documentation is impeccable.”
– Dr. Emily Zhang, Research Director, BioPeptide Labs
Don’t Risk Your Research—Choose KiloBio
Navigating ambiguous CAS numbers like 286460-71-7 requires a trusted partner. With KiloBio, you can source authentic N-Fmoc-L-phenylalanine quickly, affordably, and with confidence.
Take Action Today:
🔬 Inquire Now for a Custom Quote or email info@kilobio.com to discuss your needs.
