What Is Isopropyl Cloprostenate? Uses, Safety, and Sourcing Guide
Isopropyl Cloprostenate is a name you’ve likely encountered if you’ve researched eyelash serums, glaucoma treatments, or prostaglandin analogs. But what exactly is this compound, and why is it gaining traction in both cosmetic and medical fields? In this comprehensive guide, we’ll break down the science behind Isopropyl Cloprostenate, its applications, safety considerations, and how to source it responsibly. Whether you’re a formulator, researcher, or curious consumer, you’ll leave with a clear understanding of this powerful ingredient—and where to find high-quality Isopropyl Cloprostenate for your needs.
What Is Isopropyl Cloprostenate?
The Basics
Isopropyl Cloprostenate is a synthetic prostaglandin analog, a class of compounds that mimic naturally occurring prostaglandins (lipid molecules involved in inflammation, blood flow, and cell growth). Structurally, it’s derived from cloprostenol, a prostaglandin F2α analog, with an isopropyl ester group added to enhance stability and bioavailability.
Key Properties
- Chemical Formula: C25H35ClO6
- Molecular Weight: 467.0 g/mol
- Solubility: Lipophilic (soluble in oils and organic solvents like ethanol).
- Stability: Degrades under UV light or high heat, requiring dark, temperature-controlled storage.
How Is Isopropyl Cloprostenate Used?
1. Eyelash and Eyebrow Serums
Isopropyl Cloprostenate’s most popular application is in eyelash growth serums. It extends the anagen (growth) phase of hair follicles, resulting in longer, thicker lashes. Brands like GrandeLASH MD and RevitaLash use prostaglandin analogs, though many avoid disclosing Isopropyl Cloprostenate explicitly due to regulatory nuances.
How It Works:
- Binds to prostaglandin receptors in hair follicles.
- Increases blood flow and nutrient delivery to lash roots.
- Reduces eyelash shedding by up to 50% (based on clinical studies).
2. Glaucoma Treatment
In ophthalmology, prostaglandin analogs like Isopropyl Cloprostenate lower intraocular pressure (IOP) by increasing uveoscleral outflow of aqueous humor. While not as common as latanoprost or bimatoprost, it’s used in niche formulations.
3. Research Applications
Researchers study Isopropyl Cloprostenate for:
- Hair regrowth (scalp alopecia).
- Wound healing (via prostaglandin-mediated cell proliferation).
- Cancer studies (role in apoptosis regulation).
Is Isopropyl Cloprostenate Safe?
Benefits vs. Risks
While effective, Isopropyl Cloprostenate carries potential side effects, especially with improper use:
| Benefits | Risks |
|---|---|
| Longer, denser eyelashes | Eye irritation (redness, itching) |
| Reduced intraocular pressure | Orbital fat loss (rare) |
| Cost-effective alternative | Hyperpigmentation (eyelid darkening) |
Safety Guidelines
- Cosmetic Use: Dilute to ≤0.03% in serums.
- Medical Use: Prescription-only in most countries.
- Avoid If: Pregnant, breastfeeding, or with active eye infections.
How Isopropyl Cloprostenate Compares to Other Prostaglandin Analogs
Vs. Bimatoprost
- Similarities: Both enhance eyelash growth via prostaglandin pathways.
- Differences: Bimatoprost is FDA-approved (Latisse®), while Isopropyl Cloprostenate is often used in “cosmetic” serums to bypass drug regulations.
Vs. Latanoprost
- Potency: Isopropyl Cloprostenate has a longer half-life, requiring less frequent application.
- Cost: Typically cheaper to manufacture at scale.
Where to Source High-Quality Isopropyl Cloprostenate
Why Purity Matters
Impure or adulterated Isopropyl Cloprostenate increases side effect risks. Always verify:
- Purity ≥99% (HPLC-verified).
- Contaminant-free (heavy metals, microbes).
- Proper storage conditions (dark glass bottles, temperature-controlled).
Trusted Supplier Spotlight: KiloBio
At KiloBio, we provide lab-certified Isopropyl Cloprostenate ideal for:
- Cosmetic formulators developing eyelash serums.
- Researchers studying prostaglandin analogs.
- Pharmacies compounding glaucoma treatments.
Our Guarantee:
- ≥99.0% purity with batch-specific Certificates of Analysis (CoAs).
- Custom concentrations (powder, liquid, or pre-diluted solutions).
- Global shipping with cold-chain logistics.
👉 Request a Sample or Bulk Quote
How to Use Isopropyl Cloprostenate Safely
For Cosmetic Formulators
- Dilution: Mix with a solvent like propylene glycol or ethanol (0.01–0.03% final concentration).
- Preservation: Add antimicrobial agents (e.g., phenoxyethanol) to prevent contamination.
- Packaging: Use airless pumps or amber glass bottles to protect from light/oxygen.
For Researchers
- In vitro studies: Dissolve in DMSO or ethanol for cell culture applications.
- In vivo studies: Follow IACUC guidelines for dosing and administration.
Frequently Asked Questions
Q: Is Isopropyl Cloprostenate FDA-approved?
A: Not as a standalone drug. It’s used in cosmetics under the FDA’s “cosmetic ingredient” designation.
Q: Can I use Isopropyl Cloprostenate serum while wearing contacts?
A: No—remove contacts before application and reinsert after 15 minutes to avoid irritation.
Q: How long does it take to see results?
A: Eyelash growth typically becomes noticeable after 4–8 weeks of daily use.
Why Choose KiloBio for Your Isopropyl Cloprostenate Needs
Unmatched Quality Control
- Triple-testing protocol: Raw materials, in-process batches, and final product.
- Stability studies: 24-month shelf life guaranteed.
Transparent Pricing
- Competitive rates: From $1,800/kg (bulk discounts available).
- No hidden fees: Free CoAs and regulatory support included.
Dedicated Customer Support
- 24/7 technical assistance: Formulation advice, safety protocols, and more.
