Grubbs’ Catalyst 2nd Generation (CAS 246047-72-3) has become the gold standard for olefin metathesis, ring-opening polymerization (ROMP), and other advanced organic reactions. But what’s driving its widespread adoption? In this post, we’ll break down the cost-performance advantages of Grubbs’ Catalyst 2nd Generation, compare it to alternatives, and explain why leading labs are making the switch.
The Cost-Performance Edge of Grubbs’ Catalyst 2nd Generation
1. Superior Reaction Efficiency
Grubbs’ Catalyst 2nd Generation offers:
- Higher Yields: Up to 95% conversion rates in ROMP and cross-metathesis reactions.
- Faster Reaction Times: Reduces synthesis time by 30–50% compared to 1st-generation catalysts.
- Broader Substrate Tolerance: Works with functionalized alkenes, esters, and amines.
2. Long-Term Cost Savings
While the upfront cost may seem higher, its efficiency translates to:
- Lower Catalyst Loading: Requires 5–10x less catalyst per reaction vs. alternatives.
- Reduced Waste: Minimizes purification steps and solvent use.
- Extended Shelf Life: Stable for 24 months when stored properly.
Grubbs’ Catalyst 2nd Generation vs. Alternatives: A Cost Comparison
| Catalyst | Price/Gram | Reaction Efficiency | Substrate Tolerance | Shelf Life |
|---|---|---|---|---|
| Grubbs’ 2nd Gen | 165–165–220 | High (95% yield) | Broad | 24 months |
| Grubbs’ 1st Gen | 150–150–200 | Moderate (80% yield) | Limited | 12 months |
| Hoveyda-Grubbs | 180–180–240 | High (90% yield) | Broad | 18 months |
| Schrock Catalyst | 250–250–300 | High (85% yield) | Limited | 6 months |
Key Takeaways:
- Grubbs’ 2nd Gen offers the best balance of cost and performance.
- Hoveyda-Grubbs is slightly more expensive with comparable efficiency.
- Schrock Catalyst is cost-prohibitive for most labs due to air sensitivity and short shelf life.
Real-World Applications: Why Labs Are Switching
1. Pharmaceuticals
Grubbs’ Catalyst 2nd Generation enables:
- Efficient synthesis of macrocyclic drugs (e.g., antiviral compounds).
- Scalable production of peptide stapling agents.
2. Materials Science
- ROMP of Norbornene: Produces high-performance polymers for aerospace and electronics.
- Functionalized Cyclopentenes: Key intermediates for advanced materials.
3. Academic Research
- Cost-Effective Experiments: Reduces reagent costs for grant-funded projects.
- Reliable Reproducibility: Ensures consistent results across studies.
How to Maximize Cost Savings with Grubbs’ Catalyst 2nd Generation
1. Bulk Purchasing
Ordering in bulk slashes costs by up to 30%. For example:
- 10–50g: $185/gram.
- 100g+: $165/gram.
2. Optimize Reaction Conditions
- Use lower catalyst loadings (0.5–1 mol%) without sacrificing yield.
- Store catalyst under argon at -20°C to extend shelf life.
3. Partner with Trusted Suppliers
Choose suppliers like KiloBio for:
- Certified Quality: ≥99% purity (HPLC-verified).
- Bulk Discounts: Competitive pricing for 100g+ orders.
- Global Delivery: Ships to 50+ countries in 5–7 days.
Why KiloBio is the Top Choice
✅ Certified Quality Assurance
- Purity: ≥99% (HPLC-verified).
- Packaging: Sealed under argon in amber vials.
- CoA: Batch-specific documentation included.
✅ Transparent Pricing
No hidden fees. Our bulk rates start at $165/gram (100g+ orders).
✅ Fast Global Shipping
Guaranteed delivery in 5–7 days to the US, EU, and Asia.
Frequently Asked Questions
Q: Is Grubbs’ Catalyst 2nd Generation worth the higher upfront cost?
A: Yes – its efficiency and lower loading requirements save 20–30% in long-term costs.
Q: Can I use Grubbs’ Catalyst 2nd Generation for air-sensitive reactions?
A: Absolutely. Store and handle it under inert conditions for optimal performance.
Q: Do you offer academic discounts?
A: Yes – universities and non-profits receive an additional 5–10% discount on bulk orders.
Ready to Switch to Grubbs’ Catalyst 2nd Generation?
Don’t let high costs or inefficiencies hold back your research. Click here to request a quote for Grubbs’ Catalyst 2nd Generation (CAS 246047-72-3). With unbeatable cost-performance and certified quality, your next breakthrough is just an inquiry away.
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